default shortcut keys are:
Save picture of screen to file: ⌘⇧3
Copy picture of screen to clipboard: ⌘⌃⇧3
Save picture of selected area to file: ⌘⇧4
Copy picture of selected area to clipboard: ⌘⌃⇧4
To modify the location open a terminal window and type:
defaults write com.apple.screencapture location /Users/username
I choose to put my screenshots in a folder called 'Screenshots' which is in my Pictures folder.
To modify the format you are using type:
defaults write com.apple.screencapture type image_format
eg.
defaults write com.apple.screencapture type jpg
Replace image_format with your preferred image format; PNG, JPG, TIFF, PICT and I think PDF maybe
You may then have to logout/login to make the change(s) take effect, or try this command in your Terminal window:
killall SystemUIServer
Although Leopard may have done away with this necessity.